Biological functions of melanoma-associated antigens
نویسندگان
چکیده
منابع مشابه
Biological functions of melanoma-associated antigens.
To date, dozens of melanoma-associated antigens (MAGEs) have been identified and classified into 2 subgroups, I and II. Subgroup I consists of antigens which expression is generally restricted to tumor or germ cells, also named as cancer/testis (CT) antigen. Proteins and peptides derived from some of these antigens have been utilized in promising clinical trials of immunotherapies for gastroint...
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Soluble extracts of melanoma specimens were prepared by 3 M KCl extraction. Delayed cutaneous hypersensitivity reactions to these antigens were noted in 25 of 39 melanoma patients and 7 of 30 patients with other neoplasms. Only 4 of 34 melanoma patients reacted to an extract of autologous muscle. Maximum reactivity to these antigens occurred at 24 hr and was demonstrated histologically by skin ...
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Several studies have now clearly indicated the presence of tumor-associated and tumor-specific antigens in cells of human malignant melanoma. These antigens have been identified by means of several quite different techniques, including the use of antibodies detectable against the antigens, either by means of immunofluorescence, (1-5) cytotoxicity (4, 6, 7) or by extracting the antigen and obtai...
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Melanoma is heterogeneous for its biological properties and melanoma-associated antigens (MAAs). This diversity is partially observed in the expression of the MAAs involved with the melanin synthesis pathway. We therefore developed a sensitive multimarker reverse transcription-PCR plus Southern blot assay using five MAAs as molecular markers to detect primary and metastatic melanoma cells. Mela...
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By analyzing human melanoma cells with monoclonal antibodies (MoAb) we have identified four melanoma associated antigens with distinct tissue distribution and structural properties. They include the high molecular weight melanoma associated antigen (MAA), the Mr 120,000 MAA, the Mr 100,000 MAA, and the cytoplasmic MAA defined by MoAb 465.12. Previous studies have shown that these antigens may b...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2004
ISSN: 1007-9327
DOI: 10.3748/wjg.v10.i13.1849